Circadian rhythm of lithium toxicity in mice |
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| Authors: | Richard Hawkins Daniel F. Kripke David S. Janowsky |
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| Affiliation: | (1) Group in Physiology and Pharmacology, University of California at San Diego, San Diego, California, USA;(2) Department of Psychiatry, University of California at San Diego, San Diego, California, USA;(3) Veterans Administration Hospital, San Diego, California, USA |
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| Abstract: | The existence of cyclical (circadian) variations in lithium toxicity in mice was determined. Mice, standardized to a light-dark cycle, were injected with lithium chloride (940 mg/kg) at one of six times (20:00, 24:00, 4:00, 8:00, 12:00, and 16:00) and subsequently observed for mortality over 28 h. A significant (P<0.01) time-of-day effect was found for lithium-induced lethality, with highest lethality following injection at 12:00. |
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| Keywords: | Lithium Toxicity Circadian rhythm Mice |
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