我院2002～2005年990例药品不良反应报告回顾性分析

目的:了解我院药品不良反应(ADR)发生的特点。方法:对我院2002~2005年医务人员自愿呈报的990例ADR报告进行回顾性分析。结果:我院ADR报告总数及各类报告数均逐年增加,新的一般的ADR占9.4%,新的严重的ADR占0.8%,严重的ADR占16.3%;ADR涉及最多为皮肤及附件,其次为消化系统;可疑药品中抗感染药占总频次的45.9%,其次为抗肿瘤药;引起ADR的可疑药品以注射剂、采用静脉滴注给药方式为主;除2例死亡外,其余ADR呈报时滞均未超过规定时限。结论:应继续加强ADR监测工作,逐步提高ADR报告质量。

A Retrospective Study on 990 ADR Case Reports in Our Hospital During 2002～2005

OBJECTIVE: To study the features of the adverse drug reaction(ADR) in our hospital and to promote rational use of drugs.METHODS: A retrospective analysis was made of 990 ADR reports submitted during 2002～ 2005 by our hospital' s medical staff on their own initiative.RESULTS: The ADR reports from our hospital grew year-on-year both in the total number and the number by category.Of the 990 ADR cases,9.4% were new and common cases;0.8% ,new and serious cases;16.3%,serious cases.Skin and its appendages suffered most from ADR impairment,followed by the digestive system.Antiinfectives topped with a 45.9% proportion of the suspected drugs,followed by anticancer agents.Injections and IV administration had caused most of the ADR cases.Except for 2 death cases,all ADR reports were submitted within the stipulated time limit.CONCLUSIONS: It is suggested that ADR monitoring be further strengthened,and that the quality of ADR reports be upgraded.