Loss of orally administered drugs in GI tract |
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| Authors: | Yogeshkumar Nanasaheb Gavhane Adhikrao Vyankatrao Yadav |
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| Institution: | 1. Dept. of Pharmaceutics, Govt. College of Pharmacy, Karad (MS), India;2. Gaurishankar Education Society’s Institute of Pharmaceutical Education and Research, Limb, Satara (MS), India |
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| Abstract: | The aim of this review is to provide a broad perspective on intestinal absorption and the impact of intestinal first-pass metabolism on both clearance and drug–drug interaction prediction along with its historical perspectives. The review also considers abilities to bridge the gap between the increasing amount of intestinal in vitro data and the importance of intestinal first-pass metabolism in vivo. The significance of efflux transporters on the intestinal absorption is also discussed. |
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| Keywords: | Drug–drug interaction Efflux transporters Cytochrome P450 P-glycoprotein Gut wall/mucosal enzymes CYP3A4 |
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