Synthesis,SAR and antibacterial activity of hybrid chloro,dichloro-phenylthiazolyl-s-triazines |
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| Authors: | Prashant Gahtori Surajit Kumar Ghosh Brijesh Singh Udaya Pratap Singh Hans Raj Bhat Archana Uppal |
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| Affiliation: | 1. Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh 786004, India;2. Department of Pharmaceutical Sciences, Sam Higginbottom Institute of Agriculture Technology & Sciences (Formerly-Allahabad Agricultural Institute), Allahabad 211007, India;3. Department of Pharmaceutical Sciences, Shri Guru Ram Rai Institute of Technology & Science, Patel Nagar, Dehradun 248001, India |
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| Abstract: | A series of hybrid novel chloro (1a–9a) and dichloro (10b–18b) phenylthiazolyl-s-triazine were synthesized and subsequently subjected to their antibacterial activity against three gram positive viz. Lactobacillus casei (NCIM-2651); Bacillus cereus (NCIM-2458); Staphylococcus aureus (NCIM-2120) and three gram negative viz Salmonella typhimurium (NCIM-2501); Escherichia coli (NCIM-2065); Klebsiella aerogenes (NCIM-2098). The SAR studies around the lead compound revealed that introduction of electron withdrawing groups and amino (–NH–) and mercapto (–S–) linker bridge seemed more promising towards antibacterial activity. Moreover, the virtual Molinspiration screenings are in compliance with Ghose’s rule. |
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| Keywords: | s-Triazines Amines Linker bridge MIC Broth dilution assay |
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