A successful diagnostic case of Pneumocystis pneumonia by the loop-mediated isothermal amplification method in a patient with dermatomyositis期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

A successful diagnostic case of Pneumocystis pneumonia by the loop-mediated isothermal amplification method in a patient with dermatomyositis

Authors:	Nobuhiro Asai Masahiro Aoshima Yoshihiro Ohkuni Haruki Kobayashi Ryo Matsunuma Kei Nakashima Naoko Katsurada Norihiro Kaneko Hiroto Nakano Kazuo Matsui Yoshihito Otsuka Yasutaka Kawamura

Affiliation:	Department of Pulmonology, Kameda Medical Center, 929 Higashi-cho, Kamogawa, Chiba 296-8602, Japan;Department of Rheumatology, Kameda Medical Center, Kamogawa, Chiba, Japan;Department of Laboratory Medicine, Kameda Medical Center, Kamogawa, Chiba, Japan;Department of Radiology, Kameda Medical Center, Kamogawa, Chiba, Japan;Infectious Diseases and Clinical Microbiology Department, Dr. Lutf? K?rdar Kartal Training and Research Hospital, Istanbul, Turkey;Department of Microbiology and Clinical Microbiology, Istanbul Faculty of Medicine, National Influenza Reference Laboratory, Istanbul, Turkey;Department of Microbiology and Immunology, Teikyo University School of Medicine, Itabashi-ku, Kaga 2-11-1, 173-8605, Tokyo, Japan;The Department of Surgery I, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, 807-8555, Kitakyushu, Japan;Department of Ophthalmology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan;Department of Ophthalmology, Gifu Prefectural Gero Hot Spring Hospital, Gifu, Japan;Department of Microbiology, Gifu University Graduate School of Medicine, Gifu, Japan;Medical Mycology Research Center, Chiba University, Chiba, Japan;Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 812-8582, Fukuoka, Japan;Department of Respiratory Medicine, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, 814-0180, Fukuoka, Japan;Department of Respiratory Medicine, NHO Fukuoka-Higashi Hospital, 811-3195, Koga, Japan;Department of Respiratory Medicine, NHO Omuta Hospital, 837-0911, Omuta, Japan;Bacteriology-Virology-Hygiene Laboratory, University Hospital, Paris-Seine-Saint-Denis, Avicenne Hospital, 125, rue de Stalingrad, 93009 Bobigny Cedex, France;Intensive Care Unit, University Hospital, Paris-Seine-Saint-Denis, Avicenne Hospital, Bobigny Cedex, France;UMR-S 722, INSERM, 75018, Paris, France;Sorbonne Paris City, UMR-S 722, Xavier Bichat Medical School, Paris Nord University, 75018, Paris, France

Abstract:	Pneumocystis pneumonia (PCP) can occur in patients with many causes of the immunocompromised state other than human immunodeficiency virus (HIV). It is quite difficult to diagnose PCP without HIV because there is no method for detecting Pneumocystis jirovecii. Thus, non-HIV PCP continues to have high mortality. Recently, loop-mediated isothermal amplification (LAMP) is becoming an established nucleic acid amplification method offering rapid, accurate, and cost-effective diagnosis of infectious diseases. We report a non-HIV PCP case successfully diagnosed by the LAMP method. It was previously reported that PCR in BALF specimens had been the most sensitive method in the diagnosis of PCP without HIV. The LAMP method would be more sensitive than conventional PCR and an effective tool in the early diagnosis of PCP.

Keywords:	Loop-mediated isothermal amplification (LAMP) Dermatomyositis
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