Phosphatidylserine-expressing cell by-products in transfusion: A pro-inflammatory or an anti-inflammatory effect? |
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Authors: | P Saas F Angelot L Bardiaux E Seilles F Garnache-Ottou S Perruche |
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Institution: | 1. Inserm, UMR1098, BP 1937, 25020 Besançon cedex, France;2. Université de Franche-Comté, 25020 Besançon cedex, France;3. EFS Bourgogne Franche-Comté, 1, boulevard A-Fleming, 25020 Besançon cedex, France |
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Abstract: | Labile blood products contain phosphatidylserine-expressing cell dusts, including apoptotic cells and microparticles. These cell by-products are produced during blood product process or storage and derived from the cells of interest that exert a therapeutic effect (red blood cells or platelets). Alternatively, phosphatidylserine-expressing cell dusts may also derived from contaminating cells, such as leukocytes, or may be already present in plasma, such as platelet-derived microparticles. These cell by-products present in labile blood products can be responsible for transfusion-induced immunomodulation leading to either transfusion-related acute lung injury (TRALI) or increased occurrence of post-transfusion infections or cancer relapse. In this review, we report data from the literature and our laboratory dealing with interactions between antigen-presenting cells and phosphatidylserine-expressing cell dusts, including apoptotic leukocytes and blood cell-derived microparticles. Then, we discuss how these phosphatidylserine-expressing cell by-products may influence transfusion. |
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