| 甲氧苄氨嘧啶—PVP共沉淀物的研究 |
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| 引用本文： | 谭载友 杨兆禧. 甲氧苄氨嘧啶—PVP共沉淀物的研究[J]. 中国医院药学杂志, 1991, 11(10): 437-438 |
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| 作者姓名： | 谭载友 杨兆禧 |
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| 作者单位： | 广东医药学院药学系，广东医药学院药学系，华南理工大学化学系 广州 510224，广州 510224 90届毕业生 |
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| 摘 要： | 本工作用差示扫描量热法(DSC)研究甲氧苄氨嘧啶与PVP溶剂法制备的共沉淀物,表明已不存在甲氧苄氨嘧啶晶体。用x射线衍射法研究了1:12共沉淀物,证明无甲氧苄氨嘧啶的晶体衍射峰。经分光光度法测定结果,1:12共沉淀物比原药的溶解度大28.3倍。
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| 关 键 词： | 甲氧苄氨嘧啶 共沉淀物 差示扫描量热法 X射线衍射法 |
Study on Coprecipitate of Trimethoprime-PVP |
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| Tan Zai-you et al. Study on Coprecipitate of Trimethoprime-PVP[J]. Chinese Journal of Hospital Pharmacy, 1991, 11(10): 437-438 |
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| Authors: | Tan Zai-you et al |
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| Affiliation: | Tan Zai-you et al Department of Pharmacy,Guangdong College of Medicine and Pharmacy. Guangzhou 610224 |
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| Abstract: | The coprecipitate of trimethoprime TMP-PVP was prepared by solvent method.The DSC (differential scanning calorimetry) revealed that the TMP did not havecrystalline structure in the coprecipitate of TMP-PVP. X-ray differaction spectrumof 1: 12 coprecipitate (COPPT) showed no crystalline structure of TMP. The so-lubility of TMP in 1: 12 COPPT was about 28.3 times higher than the pure TMP. |
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| Keywords: | Trimethoprime Coprecipitate Differential Scanning calorimetry |
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