| 布洛芬片剂的溶出度研究 |
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| 引用本文： | 陆振达,赵桂萍.布洛芬片剂的溶出度研究[J].中国医院药学杂志,1991,11(5):212-214. |
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| 作者姓名： | 陆振达 赵桂萍 |
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| 作者单位： | 中国药科大学，中国药科大学，抚顺铝厂职工医院，中国药科大学，中国药科大学，中国药科大学 南京 210009，南京 210009，1989届毕业生 南京 210009，1989届毕业生 南京 210009，1989届毕业生 南京 210009 |
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| 摘 要： | 本文对国内外10个厂家的布洛芬片剂进行了体外溶出度测定。各厂布洛芬片在30分钟的溶出度均大于50%,符合美国药典21版规定。但其体外平均溶解时间(MDT)有明显区别。三种国外布洛芬片的MDT分别为5.9,6.2和14.2。国内除山东某厂布洛芬片的MDT为3.5属最低外,多数比国外产品长。本文并对改善布洛芬片溶出度的方法作了初步探讨。
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| 关 键 词： | 布洛芬片 溶出度 平均溶解时间 |
Dissolution Test on Ibuprofen Tablets |
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| Lu Zhen-da et al China Pharmaceutical University,Nanjing.Dissolution Test on Ibuprofen Tablets[J].Chinese Journal of Hospital Pharmacy,1991,11(5):212-214. |
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| Authors: | Lu Zhen-da China Pharmaceutical University Nanjing |
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| Institution: | Lu Zhen-da et al China Pharmaceutical University,Nanjing 210009 |
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| Abstract: | The dissolution of ten brands Ibuprofen tablets from ten pharmaceutical labo-ratories were de termined. It was shown that the dissolution results of all tabletsmet the standard of USP XXI (30min, >50%), but the MDTs had significant dif-ference. The MDTs of three imported products were 5.9, 6.2, 14.2min respectively.The MDT of a product from shan Dong Province was the lowest. only about 3.5minThe MDTs of most domestic products were higher than those of imported products.The dissolution could be improved by useing excipients such as CMS-Na andL-HPC. |
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| Keywords: | Ibuprofen Dissolution MDT |
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