| 白念珠菌多药耐药蛋白Cdr1p和Cdr2p的研究进展 |
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| 引用本文： | 贾鑫明,高平挥,曹永兵,姜远英. 白念珠菌多药耐药蛋白Cdr1p和Cdr2p的研究进展[J]. 第二军医大学学报, 2004, 25(4): 437-439 |
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| 作者姓名： | 贾鑫明 高平挥 曹永兵 姜远英 |
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| 作者单位： | 第二军医大学药学院药理学教研室,上海,200433;第二军医大学药学院药理学教研室,上海,200433;第二军医大学药学院药理学教研室,上海,200433;第二军医大学药学院药理学教研室,上海,200433 |
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| 基金项目： | 国家自然科学基金 ( C0 3 0 2 0 7) |
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| 摘 要： | ABC转运蛋白(ATP—binding cassette transporter，ABCT)属于膜转运蛋白，存在于哺乳动物、细菌、真菌等多种细胞中，且与多种细胞的多药耐药(multidrug resistance，MDR)有关。白念珠菌(Candida albicans)含有多种ABCT，但只有Cdr1p、Cdr2p与MDR有关；另外，Cdr1p、Cdr2p具有外排泵、磷脂易位等功能。本文对白念珠菌耐药蛋白的研究进展作一综述。
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| 关 键 词： | ABC转运蛋白 白念珠菌 多药耐药 Cdr1p Cdr2p |
| 文章编号： | 0258-879X(2004)04-0437-03 |
| 修稿时间： | 2003-10-31 |
Progress in Cdr1p and Cdr2p proteins mediating multidrug resistance in Candida albicans |
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| JIA Xin Ming,GAO Ping Hui,CAO Yong Bing,JIANG Yuan Ying. Progress in Cdr1p and Cdr2p proteins mediating multidrug resistance in Candida albicans[J]. Former Academic Journal of Second Military Medical University, 2004, 25(4): 437-439 |
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| Authors: | JIA Xin Ming GAO Ping Hui CAO Yong Bing JIANG Yuan Ying |
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| Affiliation: | JIA Xin Ming,GAO Ping Hui,CAO Yong Bing,JIANG Yuan Ying * |
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| Abstract: | ATP binding cassette transporter (ABCT),a membrane transporting protein existing in mammalian, bacterial, fungal and many other types of cells, is correlated with multidrug resistance in many cells. To date 10 ABCT have been described in Candida albicans , but only CDR1 and CDR2 genes were associated with multidrug resistance. Moreover, their encoding proteins Cdr1p and Cdr2p have many functions such as efflux pump and phospholipid translocator. The progress in the study of Cdr1p and Cdr2p proteins mediating multidrug resistance in Candida albicans was summarized in the paper. |
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| Keywords: | ATP binding cassette transporter Candida albicans multidrug resistance Cdr1p Cdr2p |
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