首页 | 本学科首页   官方微博 | 高级检索  
     

P16蛋白在膀胱移行细胞癌中的表达及意义
引用本文:王春英 陈廷. P16蛋白在膀胱移行细胞癌中的表达及意义[J]. 济宁医学院学报, 1999, 22(4): 7-8
作者姓名:王春英 陈廷
作者单位:临沂市肿瘤医院(王春英),济宁医学院微生物学教研室(陈廷,曹卉,衣美英,朱伟,李秀真,刘昌平,山长武)
基金项目:山东省自然科学基金!(Y95C0931) 资助
摘    要:目的 探讨P16 基因蛋白表达与膀胱移行细胞癌的相关性。方法 采用免疫组化SP法检测75 例膀胱移行细胞癌组织P16 基因表达。结果 P16 蛋白异常表达率为41 .3% (31/75) ,P16 阳性表达率与肿瘤病理分级、临床分期有密切关系( P< 0 .05) ,与淋巴结及远处转移无关( P> 0.05)。结论 P16 蛋白的异常表达与膀胱癌的恶性程度、浸润性有关。

关 键 词:膀胱移行细胞癌  基因  免疫组化

EXPRESSION OF P16 GENE IN BLADDER TRANSITIONAL CELL CARCINOMA
Wang Chunying,Chen Ting,Cao Hui,et al.. EXPRESSION OF P16 GENE IN BLADDER TRANSITIONAL CELL CARCINOMA[J]. Jounal of Jinning Medical College, 1999, 22(4): 7-8
Authors:Wang Chunying  Chen Ting  Cao Hui  et al.
Affiliation:Lin Yi Carcinorma Hospital
Abstract:Objective The?study?of?correlation?of?p16?protein?expression?with?bladdertransitional cell carcinoma. Methods We used Immunohistochemisty SP method to detecting P16 gene expression in 75 cases of bladder carcinoma.Results Positive expression rate of P16 gene was 41.3%(31/75), P16 gene positive expression rate was related closely to the tumor grade, clinic stage(P<0.05), but was not related to the metastasis(P>0.05).Conclusion P16 protein expression might be as a tumor marker for the maligant potential.
Keywords:Bladder transitional cell carcinoma Gene Immunohistochemisty
本文献已被 CNKI 维普 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号