国产环丙沙星注射液临床疗效的观察

目的 :评价国产环丙沙星注射液治疗下呼吸道、泌尿系及伤寒等细菌性感染的临床疗效、细菌学疗效和安全性。方法 :采用随机对照开放试验的方法 ,对国产环丙沙星注射液的临床疗效和细菌清除率进行了观察。结果 :国产环丙沙星注射液临床疗效有效率 84.0 % ,痊愈率 56.0 % ,与对照组头孢氨噻肟疗效一致 ,无显著性差异 ( P>0 .0 5)。国产环丙沙星注射液细菌清除率 76.9% ,与头孢氨噻肟比较疗效接近 ( P>0 .0 5) ,对肺炎克雷伯杆菌、大肠杆菌、变形杆菌、枸橼酸杆菌、伤寒杆菌及不动杆菌具有良好的清除作用 ,对铜绿假单胞菌亦有满意的抗菌活性。不良反应轻微 ,用药安全。结论 :国产环丙沙星注射液为广谱、高效、安全的抗菌药物 ,对不能耐受口服制剂者可避免胃肠道的直接刺激作用 ,对重症不能口服者提供了很好的给药途径

OBSERVATION ON CLINICAL THERAPENTIC EFFECT OF DOMESTIC INTRAVENOUS PREPARATION OF CIPROFLOXACIN

Objective:To evaluate the clinical efficacy, bacteriological efficacy and safety of domestic intravenous preparation of ciprofloxacin on lower respiratory tract, urinary tract bacterial infections and typhoid fever Methods:A randomized controlled study was carried out to treat bacterial infections with domestic ciprofloxacin and to compare with domestic cefotaxime sodium Results:The total clinical efficacy rate of domestic ciprofloxacin was 84 0%,the cure rate was 56 0%,the bacterial clearance rate was 76 9%,there was no statistically significant difference between 2 groups ( P >0 05) There was no statistical difference between the incidence of adverse reactions in domestic ciprofloxacin group and that on domestic cefotaxime sodium ( P >0 05) Conclusion:The domestic intravenous preparation of ciprofloxacin is an antibiotic of broad spectrum, high efficacy and safety It is suitable for treating severe bacterial infections