丹参对被动吸烟所致大鼠肝功能变化的影响

目的 :探讨丹参对被动吸烟所致肝功能变化的保护作用及其机制。方法 :用香烟烟雾使大鼠被动吸烟的方法 ,复制肝损伤的动物模型。以 0 .3ml丹参注射液给模型鼠腹腔注射 ,观察丹参对吸烟所致大鼠肝功能及肝系数改变的影响。结果 :烟熏组大鼠肝功能检查结果明显异常 ( P<0 .0 5) ,肝系数明显增高 ( P<0 .0 5) ;丹参 烟熏组大鼠肝功能明显优于烟熏组 ( P<0 .0 5)且与正常对照组无显著性差异 ( P>0 .0 5)。肝系数明显低于烟熏组 ( P<0 .0 5)且于正常对照组相近似 ( P>0 .0 5)。结论 :丹参对被动吸烟所致大鼠肝功能及肝系数的改变有较好的保护作用 ,其机制可能主要与抗氧自由基的损伤有关

IMPACTS OF SALVIA MILTIORRHIZA ON THE CHANGES IN RATS' LIVER FUNCTION CAUSED BY PASSIVE SMOKING

Objective: To discuss the protection and mechanism of salvia miltiorrhiza in the changes in rats' liver function caused by cigarette smoking Methods: The test makes rats smoke passively by cigarette smoking and duplicates the animal model of liver injury 0 3 ml of salvia miltiorrhiza is injected intraperitoneally into the rats, observations are made on the changes in rats' liver function and their liver coefficient caused by smoking Results: Examination results of the rats' liver function show obvious changes in the smoking group, their liver coefficient increases clearly and shows great distinctioin from that in the mormal group The rats' liver function in the smoking and salvia miltiorrhiza group becomes superior to that in the smoking group, their liver coefficient is also lower than that in the smoking group and similar to that in the normal group Conclusion: Salvia miltiorrhiza has positive impacts on the changes ini rats' liver function and their liver coefficient caused by passive smoking Its mechanism may be related to the injury in anti oxygen free eadicals