Chronic Dietary Toxicity/Oncogenicity Studies on 2,4-Dichlorophenoxyacetic Acid in Rodents |
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Authors: | CHARLES, JEFFREY M. BOND, DENISE M. JEFFRIES, TONI K. YANO, BARRY L. STOTT, WILLIAM T. JOHNSON, KEITH A. CUNNY, HELEN C. WILSON, RONALD D. BUS, JAMES S. |
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Affiliation: | *Charles, Conn, & van Gemert, LLC Durham, North Carolina 27705 Dow Chemical Company Midland, Michigan 43674-0001 Rhone-Poulenc Ag Company Research Triangle Park, North Carolina 27705 John Wise & Associates, Ltd. Liberry, Missouri 64068 Received May 15, 1996; accepted May 18, 1996 |
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Abstract: | Forms of 2,4-dichlorophenoxyacetic acid (collectively knownas 2,4-D) are herbicides used to control a wide variety of broadleafand woody plants. Doses in the 2-year chronic/oncogenicity ratstudy were 0, 5, 75, and 150 mg/kg/day. The chronic toxicityparalleled subchronic findings, and a NOEL of 5 mg/kg/day wasestablished. A slight increase in astrocytomas observed (inmales only) at 45 mg/kg/day in a previously conducted chronicrat study was not confirmed in the present study at the highdose of 150 mg/kg/day. Doses in the 2-year mouse oncogenicitystudies were 0, 5, 150, and 300 mg/kg/day for females and 0,5, 62.5, and 125 mg/kg/day for males. No oncogenic effect wasnoted in the study. In summary, the findings of these studiesindicate low chronic toxicity of 2,4-D and the lack of oncogenicresponse to 2,4-D following chronic dietary exposure of 2,4-Din the rat and mouse. |
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