| 丹皮酚对水应激所致小鼠胃溃疡保护作用的实验研究 |
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| 引用本文： | 周源,杨小红,盛习锋,王珊珊. 丹皮酚对水应激所致小鼠胃溃疡保护作用的实验研究[J]. 湖南师范大学学报(医学版), 2007, 4(4): 11-13 |
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| 作者姓名： | 周源 杨小红 盛习锋 王珊珊 |
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| 作者单位： | 湖南师范大学医学院基础医学系;湖南师范大学医学院药学系;湖南师范大学,长沙,410006 |
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| 基金项目： | 湖南省卫生厅科研计划项目(B2005111)，湖南省中医药管理局科研基金资助项目(6304-66) |
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| 摘 要： | 目的:观察丹皮酚对水应激所致小鼠胃溃疡模型的保护作用。方法:采用水应激诱导小鼠急性胃粘膜损伤,灌胃给予丹皮酚(50,100mg/kg),每天一次,连续5天,以溃疡指数及胃粘膜形态学改变为观察指标,探讨丹皮酚对水应激所致小鼠胃粘膜损伤的影响并与奥美拉唑比较。结果:丹皮酚对水应激所致小鼠胃溃疡有保护作用,剂量增大溃疡指数减小更加明显,胃黏膜损伤程度减轻;丹皮酚的抗溃疡强度与奥美拉唑相似。结论:丹皮酚可显著减轻水应激引起的胃黏膜损伤。
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| 关 键 词： | 丹皮酚 胃溃疡 溃疡指数 小鼠 |
| 文章编号： | 1673-016x(2007)04-0011-02 |
| 修稿时间： | 2007-09-20 |
Protective Effects of the Paeonol in Experimental Gastric Ulcer on Mice |
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| ZHOU Yuan,SHENG Xi-feng,YANG Xiao-hong,WANG Shan-shan. Protective Effects of the Paeonol in Experimental Gastric Ulcer on Mice[J]. Journal of Hunan Normal University(Medical Science), 2007, 4(4): 11-13 |
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| Authors: | ZHOU Yuan SHENG Xi-feng YANG Xiao-hong WANG Shan-shan |
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| Abstract: | Objective To observe the protective effects of paeonol in experimental gastric ulcer on mice.Methods The mice gastric ulcer model was induced by WRS;the extent of gastric mucosal injury was evaluated grossly(index of ulcer) and histologically.Results Paeonol play a protective effect in experimental gastric ulcer induced by WRS.The protective effect of paeonol is similar to omeprazole.Conclusion Paeonol could protect the gastric mucosa from injury induced by WRS on mice. |
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| Keywords: | paeonol gastric ulcer index of ulcer mice |
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