|
|||||
|
|
Interleukin-6 gene polymorphism in febrile seizures |
|
| Authors: | Nur Banu Guzel Kahramaner Zelal Duman Ozgur Dundar Nihal Olgac Sallakcı Nilgun Yavuzer Ugur Haspolat Senay |
| Affiliation: | a Department of Pediatrics, Antalya Education and Research Hospital, Antalya, Turkey b Department of Pediatrics, Tepecik Education and Research Hospital, Izmir, Turkey c Division of Child Neurology, Department of Pediatrics, School of Medicine, Akdeniz University, Antalya, Turkey d Department of Child Neurology, School of Medicine, Suleyman Demirel University, Isparta, Turkey e Department of Child Immunology, School of Medicine, Akdeniz University, Antalya, Turkey f Department of Physiology, School of Medicine, Akdeniz University, Antalya, Turkey |
| Abstract: | Febrile seizures comprise a common type of pediatric convulsion. Inflammation and genetics may be involved in their pathogenesis. Regarding the role of cytokines (especially interleukin-6) in febrile responses, we performed a case control study of interleukin-6 gene (−174, −572, and −597) single-nucleotide polymorphisms to learn if correlations existed between these particular polymorphisms and febrile seizures. We isolated the genomic DNA of 92 children with febrile seizures and 98 healthy control subjects. We genotyped individuals for their polymorphisms, using polymerase chain reaction-restriction fragment length polymorphism. In our study, the frequencies of −174 G alleles and of the −174 and −572 GG genotypes were observed to be significantly higher in patients than in control subjects. The −174 GG genotype frequency was significantly higher in children with a family history of febrile seizures. |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |