习惯性流产患者宫内膜雌孕激素受体及血雌孕激素的测定

为从激素及受体的角度对习惯性流产的病因进行探讨，作者采用葡聚糖活性炭分离单点饱和分析法测定８例习惯性流产患者宫内膜增生期及分泌期雌孕激素受体，同时作宫内膜的病理组织学检查及血雌孕激素水平的测定。结果表明：血雌二醇水平在正常范围，８例患者中有５例孕酮水平在分泌期低于１１ｎｇ／ｍｌ。雌激素受体含量与正常比较无显著性差异；孕激素受体在增生期及分泌期均低于正常生育妇女宫内膜孕激素受体含量。雌孕激素受体含量及血雌孕激素之间无相关性；宫内膜病理检查未发现分泌功能不足的情况。以上提示孕激素水平及宫内膜孕激素受体含量低，可能为习惯性流产的原因之一。

A Measurement of Cytoplasmic Estradiol and Progesterone Receptors in Endometrium of Patients with Habitual Abortion

Estradiol and progesterone receptors in the endometrium of eight patients with habitual abortion in proliferative and secretory phases were measured by DCC.The serum estradiol (E2) and progesterone (P) were detected by radioimmunoassay,and the endometrium was histologically studied.The results showed that the level of serum E2 was normal in the proliferative and secretory phases.In 5/8 patients,the serum P level was below 11 ng/ml.The estradiol receptor of patients was not different from that of normal women in the proliferative and secretory phases,but the progesterone receptor was significantly lower than that of normal women in the proliferative and secretory phases.These suggest that the lower level of progesterone and progesterone receptor in the endometrium may be one of the causes of habitual abortion.