Phospholipase A2 activation is not required for long-term synaptic depression |
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| Affiliation: | 1. Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461-1602, USA;2. Department of Neurology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461-1602, USA;1. Dokuz Eylul University, Izmir Vocational School, Department of Technical Programs, Education Campus Buca, Izmir, Turkey;2. University of Ontario Institute of Technology, Faculty of Engineering and Applied Science, Mechanical Engineering Department, 2000 Simcoe Street North, Oshawa, Ont., L1H 7K4, Canada;3. Yildiz Technical University, Faculty of Mechanical Engineering, Besiktas, Istanbul, Turkey;1. Department of Organic and Polymeric Materials, Tokyo Institute of Technology, O-okayama, Meguro-ku, Tokyo, 152-8552, Japan;2. The Institute for Solid State Physics, The University of Tokyo, Kashiwa, Chiba, 277-8581, Japan;3. Graduate School of Material Science, University of Hyogo, Kamigori, Hyogo, 678-1205, Japan;4. ACT-C, JST, Honcho, Kawaguchi, Saitama, 332-0012, Japan;1. Department of Metallurgical and Materials Engineering, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal, India;2. School of Nano Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal, India;3. Materials Science Center, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal, India;1. Centre Hospitalier Universitaire de Bordeaux, Universitaire de Bordeaux, Centre de Recherche Cardio-Thoracique de Bordeaux, INSERM U-1045, Bordeaux, France;2. Service de Médecine Nucléaire, Hôpital du Haut-Lévèque, Pessac 33604, France |
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| Abstract: | Low-frequency synaptic stimulation evokes long-term depression of synaptic strength. One hypothesis is that modification of AMPA receptors by phospholipase A2 causes long-term depression. A previous study reported bromophenacylbromide, a completely nonselective phospholipase A2 inhibitor, blocked long-term depression at Schaffer collateral-CA1 synapses in hippocampus. In contrast, I show here that 3-(4-octadecyl)-benzoylacrylic acid (OBAA), a much more potent and selective inhibitor of low and high molecular weight phospholipase A2, does not block long-term depression at these same synapses, indicating that phospholipase A2 is not necessary for modifications causing long-term depression. |
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