Effect and Tolerability of a Nutritional Supplement Based on a Synergistic Combination of β-Glucans and Selenium- and Zinc-Enriched Saccharomyces cerevisiae (ABB C1®) in Volunteers Receiving the Influenza or the COVID-19 Vaccine: A Randomized,Double-Blind,Placebo-Controlled Study |
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Authors: | Juliá n André s Mateus Rodriguez,Mó nica Bifano,Elvira Roca Goma,Carlos Mé ndez Plasencia,Anna Olivé Torralba,Mercè Santó Font,Pedro Roy Millá n |
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Affiliation: | 1.Hospital Mare de Déu de la Mercè, Hermanas Hospitalarias, 08042 Barcelona, Spain; (M.B.); (C.M.P.); (A.O.T.); (M.S.F.); (P.R.M.);2.Clinica Nostra Senyora del Remei, 08024 Barcelona, Spain;3.CBC Isabel Roig, 08030 Barcelona, Spain;4.Unitat Polivalent Barcelona Nord, Hermanas Hospitalarias, 08035 Barcelona, Spain; |
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Abstract: | A single-center, randomized, double-blind, placebo-controlled study was conducted in 72 volunteers who received a synergistic combination of yeast-based ingredients with a unique β-1,3/1,6-glucan complex and a consortium of heat-treated probiotic Saccharomyces cerevisiae rich in selenium and zinc (ABB C1®) or placebo on the next day after getting vaccinated against influenza (Chiromas®) (n = 34) or the COVID-19 (Comirnaty®) (n = 38). The duration of treatment was 30 and 35 days for the influenza and COVID-19 vaccine groups, respectively. Mean levels of CD4+T cells increased from 910.7 at baseline to 1000.2 cells/µL after the second dose of the COVID-19 vaccine in the ABB C1® group, whereas there was a decrease from 1055.1 to 929.8 cells/µL in the placebo group. Changes of CD3+T and CD8+T lymphocytes showed a similar trend. In the COVID-19 cohort, the increases in both IgG and IgM were higher in the ABB C1® supplement than in the placebo group. Serum levels of selenium and zinc showed a higher increase in subjects treated with the active product than in those receiving placebo. No serious adverse events related to ABB C1® or tolerance issues were reported. The study findings validate the capacity of the ABB C1® product to stimulate trained immunity. |
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Keywords: | trained immunity, influenza vaccine, COVID-19 vaccine, β -1,3/1,6-glucan complex, selenium, zinc, Saccharomyces cerevisiae, nutritional supplementation |
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