High expression levels of IKK alpha and IKK beta are necessary for the malignant properties of liver cancer |
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| Authors: | Jiang RQ Xia YX Li J Deng L Zhao Shi Wang XH Sun BC Nanjing Med Univ Liver Transplantat Ctr Affiliated Hosp Nanjing Jiangsu Prov Peoples R China Nanjing Med Univ Ctr Canc |
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| Institution: | Jiang,RQ,Xia,YX,Li,J,Deng,L,Zhao,Shi,Wang,XH,Sun,BC Nanjing Med Univ,Liver Transplantat Ctr,Affiliated Hosp 1,Nanjing,Jiangsu Prov,Peoples R China,Nanjing Med Univ,Ctr Canc |
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| Abstract: | IKK-NF-kappa B signaling is regarded as an important factor in hepatocarcinogenesis and a potential target for liver cancer therapy.Therefore,in this study,we analyzed the expression of mRNAs encoding components and targets of NF-kappa B signaling including IKK alpha,IKK beta,RANK,RANKL,OPG,CyclinD3,mammary serine protease inhibitor(Maspin),CyclinD1,c-FLIP,Bcl-x1,Stat3,Cip1 and Cip2 by real-time PCR in 40 patients with liver cancer.After statistical analysis,7 indices including IKK alpha,IKK beta,RANK,Maspi... |
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| Keywords: | liver cancer NF-kappa B lentiviral vector small interference RNA |
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