The Effect of Etiocholanolone on Granulocyte Kinetics |
| |
| Authors: | VOGEL, JAMES M. YANKEE, RONALD A. KIMBALL, HARRY R. WOLFF, SHELDON M. PERRY, SEYMOUR |
| |
| Affiliation: | 1 Medicine Branch, National Cancer Institute, and the Clinical PhysiologySection, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland.
|
| |
| Abstract: | The effect of etiocholanolone on granulocyte kinetics in 12 hematologicallynormal patients has been investigated using the technic of 3H-DFP labelingof autologous blood in vitro.Baseline determinations of the total blood granulocyte pool (TBGP), thecirculating pool (CGP), and the marginated pool (MGP) were performed.The values for the total blood granulocyte pools were similar to those previously reported. Following the administration of etiocholanolone, there was a98 per cent increase in the TBGP, which was considered to be due to mobilization of granulocytes from the bone marrow reserve. There was no change inthe ratio of CGP to MGP.These studies suggest that etiocholanolone may be a useful agent for theestimation of bone marrow reserve. Submitted on November 21, 1966 Accepted on April 13, 1967 |
| |
| Keywords: | |
|
| 点击此处可从《Blood》浏览原始摘要信息 |
|
点击此处可从《Blood》下载全文 |
|
