Moderate alcohol consumption and lower total mortality risk: Justified doubts or established facts? |
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Authors: | Simona Costanzo Giovanni de Gaetano Augusto Di Castelnuovo Luc Djoussé Andrea Poli David P van Velden |
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Institution: | 1. Department of Epidemiology and Prevention, IRCCS NEUROMED, Pozzilli, IS, Italy;2. Mediterranea Cardiocentro, Napoli, Italy;3. Division of Aging, Department of Medicine, Brigham and Women''s Hospital and Harvard Medical School, Boston, MA, USA;4. Massachusetts Veterans Epidemiology and Research Information Center (MAVERIC), Boston Veterans Affairs Healthcare System, Boston, MA, USA;5. NFI (Nutrition Foundation of Italy), Viale Tunisia 38, 20124, Milan, Italy;6. Department of Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa |
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Abstract: | For almost a century, the scientific community is aware of the J-shaped curve between alcohol consumption and all-cause mortality. Moderate drinkers seem to live longer than both abstainers and heavy drinkers. These epidemiological observations regarding moderate alcohol consumption and beneficial health effects have been incessantly scrutinised for confounding and bias. This viewpoint discusses previous and recent criticisms regarding the J-shaped curve between alcohol consumption and total mortality risk. The controversies regarding the J-shaped curve between alcohol consumption and mortality are ongoing, as well as the debate among scientists in this area of research, resulting in conflicting messages in media and in different alcohol guidelines. Although it appears quite difficult to come up with a position statement only based on the currently available scientific data, it is imperative to fairly inform the public, without creating confusion and, worst case, disbelief in science. |
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Keywords: | Corresponding author Laboratory of Molecular and Nutritional Epidemiology Department of Epidemiology and Prevention IRCCS NEUROMED Via dell’Elettronica 86077 Pozzilli IS Italy Moderate alcohol consumption All-cause mortality Criticisms |
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