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A double-blind placebo controlled trial into the impacts of HMB supplementation and exercise on free-living muscle protein synthesis,muscle mass and function,in older adults
Authors:U.S.U. Din  M.S. Brook  A. Selby  J. Quinlan  C. Boereboom  H. Abdullah  M. Franchi  M.V. Narici  B.E. Phillips  J.W. Williams  J.A. Rathmacher  D.J. Wilkinson  P.J. Atherton  K. Smith
Affiliation:1. MRC-ARUK Centre for Musculoskeletal Ageing Research, Clinical, Metabolic and Molecular Physiology, University of Nottingham, Royal Derby Hospital Centre, Derby, UK;2. Nottingham NIHR BRC, UK;3. Metabolic Technologies, Inc, Iowa State University Research Park, 2711 S. Loop Drive, Ste 4400, Ames, IA, 50010, USA
Abstract:
Keywords:Corresponding author. MRC-ARUK Centre for Musculoskeletal Ageing Research, Clinical, Metabolic and Molecular Physiology, Royal Derby Hospital Centre, NIHR Nottingham BRC, University of Nottingham, Uttoxeter Road, Derby, DE22 3DT, UK.  Skeletal muscle  HMB  Stable isotopes  Exercise  Deuterium oxide  MVC  Maximal voluntary contraction  RET  Resistance exercise training  1-RM  One repetition maximum  TC/EA  High temperature conversion elemental analyser  GC  Gas chromatography  IRMS  Isotope ratio mass spectrometer  MPS  Muscle protein synthesis  USG  Ultrasonography  DXA  Dual-energy X-ray absorptiometry  VL  Vastus lateralis  MCME  APE  Atom percent excess  RPE- Rating of perceived exertion  PLA- Placebo  HMB  β-hydroxy-β-methyl-butyrate  HMB-FA  Free Acid β-hydroxy-β-methyl-butyrate  UT  Untrained leg  RE  Resistance exercise
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