Protective association of HLA-DRB1*13:02, HLA-DRB1*04:06, and HLA-DQB1*06:04 alleles with cervical cancer in a Korean population |
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| Authors: | Hyoeun Shim Boram Park Hye-Jin Shin Jungnam Joo Kyong-Ah Yoon Young Min Kim Tomonori Hayashi Katsushi Tokunaga Sun-Young Kong Joo-Young Kim |
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| Affiliation: | 1. Department of Laboratory Medicine, National Cancer Center, Goyang, Republic of Korea;2. Biometrics Research Branch, National Cancer Center, Goyang, Republic of Korea;3. Particle Therapy Research Branch, National Cancer Center, Goyang, Republic of Korea;4. College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea;5. Department of Statistics, Kyungpook National University, Daegu, Republic of Korea;6. Department of Radiobiology and Molecular Epidemiology, Radiation Effects Research Foundation, Hiroshima, Japan;7. Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan;8. Translational Research Branch, National Cancer Center, Goyang, Republic of Korea |
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| Abstract: | Human leukocyte antigen (HLA) class II alleles have been previously associated with cervical cancer. However, these associations vary widely across racial and ethnic groups. Therefore, we evaluated the effect of HLA class II alleles on cervical cancer in a Korean population. HLA-DRB1, HLA-DQB1, and HLA-DQA1 alleles were analyzed in 457 cervical cancer patients and compared to those of 926 control subjects. The odds ratio (OR) of each allele between the patients and controls was calculated using the logistic regression model. Patients, had significantly lower frequencies of HLA-DRB1 and HLA-DQB1 alleles than control subjects: HLA-DRB1*13:02:01 (4.4% vs 8.8%; OR 0.48, 95% confidence interval (CI) 0.27–0.84; p = 0.001), HLA-DRB1*04:06 (2.1% vs 4.7%; OR 0.44, 95% CI 0.20–0.97; p = 0.033), and HLA-DQB1*06:04:01 (2.3% vs 5.0%; OR 0.46, 95% CI 0.22–0.94; p = 0.021). No significant association was observed for HLA-DQA1. Protective associations between HLA-DRB1*13:02, HLA-DRB1*04:06, and HLA-DQB1*06:04 alleles and cervical cancer were found in the Korean population |
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| Keywords: | Corresponding authors at: National Cancer Center 323 Ilsan-ro Ilsandong-gu Goyang-si Gyeonggi-do 10408 Republic of Korea. |
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