?????????к?????10?????????????

Variation of pathogens and analysis of drug resistance of bacterial diarrhea in children during recent 10 years.

??Abstract?? Objective??To study variation of pathogens of bacterial diarrhea in children during recent 10 years?? and to analyze drug resistance of these bacterial strains. Methods??A total of 859 cases?? who were hospitalized in Beijing Children’s Hospital due to bacterial diarrhea from 1998 to 2007??with positive stool culture?? were included in our study. And their clinical data were also studied retrospectively. Statistics was analyzed by SPSS13.0. Results????1??Among 859 bacterial trains of positive stool culture?? there were 585 Shigella??89 Salmonella??56 E coli??92 Proteus?? and 37 Staphylococcus aureus. ??2??The ratio of Shigella decreased from 82.5% of 1998 to 52.9% of 2007.Detection of Staphylococcus aureus and E coli were began at 2001 and 2002?? respectively?? and their ratios gradually increased to 9.4% and 14.1% in 2007?? respectively. ??3??The peak onset??73.9%?? of bacterial diarrhea was in summer and autumn. Salmonella?? E coli?? and conditional pathogenic bacteria were found with high detection ratio in younger-aged group. ??4??The drug resistance ratio of enteric pathogenic bacteria to penicillin and sulfamethoxazole were both above 50%. Except E coli?? the enteric pathogens showed low drug resistance to quinolones?? third generation cephalosporins and imipenem?? with ratios of 13.0????24.2%??5.9????62.5% and 0??respectively. The resistance ratios of E coli to amikacin and imipenem were 7.5% and 0%??respectively?? and its ratios to other antibiotics were all above 50%. Conclusion??The structure of pathogens of bacterial diarrhea in children and their drug resistance pattern are changing continuously. It should be emphasized to monitor pathogens and drug resistance in order to select antibiotics reasonably.