Association of MDM2 gene SNP 309 polymorphism and human non-small cell lung cancer susceptibility: A meta-analysis

This updated meta-analysis was performed to evaluate the relationship of a common polymorphism (T309 G, rs2279744 T > G) in the murine double minute 2 (MDM2) gene with susceptibility and prognosis of non-small cell lung cancer (NSCLC). The Cochrane Library, PubMed, Embase, CNKI, WanFang and CNKI databases were searched comprehensively for related study. Odds ratios (ORs) with their 95% confidence intervals (95% CI) were calculated. 11 articles with a total 6470 NSCLC patients and 8027 controls met the inclusion criteria were included. MDM2 T309 G polymorphism might be strongly correlated with an increased risk of NSCLC. The overall pooled analysis indicated that MDM2 309 T/G polymorphism was significantly associated with NSCLC susceptibility in the whole population under allelic (OR: 1.22, 95% CI: 1.08–1.38), recessive (OR: 1.37, 95% CI: 1.15–1.63), dominant (OR: 1.23, 95% CI: 1.04–1.45), and homozygous genetic models (OR: 1.49, 95% CI: 1.20–1.86). The subgroup analysis showed a significant association of MDM2 309 T/G polymorphism with NSCLC susceptibility in Asian population, but not in Caucasian population. Besides, a significant association was found again in the female population. The meta-analysis provides convincing evidence that the MDM2 T309 G polymorphism may contribute to NSCLC susceptibility, especially for Asians and women.