Variable waveforms in downbeat nystagmus imply short-term gain changes |
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Authors: | Abel L A Traccis S Dell'Osso L F Ansevin C F |
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Institution: | Ocular Motor Neurophysiology Laboratory, Veterans Administration Medical Center, Cleveland, OH, USA. |
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Abstract: | A patient with downbeat nystagmus subsequent to ankylosing spondylitis was studied. His nystagmus was found to exhibit both increasing- and decreasing-velocity exponential slow phases as well as the linear form more often reported. Alternation between waveforms sometimes occurred on a beat-to-beat or even intrabeat basis. Possible explanations for all three waveforms are presented in terms of short-term gain changes in cerebellar compensation for leaky brainstem neural integrators. A computer model was developed and its results are discussed. |
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