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| 重楼对多发性创伤大鼠的保护作用 | |
| 引用本文： | 周满红,李建国,黄祖敏,郑亚玉,张永萍,肖雪,万卫红.重楼对多发性创伤大鼠的保护作用[J].遵义医学院学报,2008,31(5). |
| 作者姓名： | 周满红 李建国 黄祖敏 郑亚玉 张永萍 肖雪 万卫红 |
| 作者单位： | 1. 遵义医学院附属医院,急诊科,贵州,遵义,563003 2. 贵阳中医学院,药物制剂实验室,贵州,贵阳,550002 3. 贵州省细胞工程重点实验室,贵州,遵义,563003 |
| 基金项目： | 贵州省科技厅 |
| 摘 要： | 目的探讨重楼总皂苷(RPTS)对多发性创伤模型大鼠的保护作用。方法将70只Wistar大鼠随机分成3组,除空白对照组外,其余2组按多发骨折-脂多糖两次打击致多发性创伤并急性肺损伤动物模型标准制模,制模后1h,重楼干预组予重楼总皂苷(RPTS)灌胃。干预后6h,部分动物采血,以ELISA法检测血清中TNF-α、IL-1β及IL-6浓度;各组留取肺组织,光镜下进行病理形态观察。剩余动物用以观察死亡率。结果重楼干预组大鼠血清TNF-α、IL-1β及IL-6浓度显著低于模型对照组(P<0.001)。模型对照组,光镜下肺组织病理形态观察显示明显肺损伤;而重楼干预组肺损伤表现明显轻于模型对照组。死亡率,重楼干预组显著低于模型对照组(P<0.05)。结论重楼总皂苷对多发性创伤大鼠具有保护作用,机制可能与下调血清中的TNF-α、IL-1β、IL-6水平从而减轻炎症反应以及减轻急性肺损伤有关。 |
| 关 键 词： | 重楼总皂苷 多发性创伤 肿瘤坏死因子-α 白细胞介素-1β 白细胞介素-6 脂多糖 急性肺损伤 死亡率 |
Protective effects of Rhizoma Paridis total saponins on the rats subjected to multiple trauma |
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| ZHOU Man-hong,LI Jian-guo,HUANG Zu-min,ZHENG Ya-yu,ZHANG Yong-ping,XIAO Xue,WAN Wei-hong.Protective effects of Rhizoma Paridis total saponins on the rats subjected to multiple trauma[J].Acta Academiae Medicine Zunyi,2008,31(5). | |
| Authors: | ZHOU Man-hong LI Jian-guo HUANG Zu-min ZHENG Ya-yu ZHANG Yong-ping XIAO Xue WAN Wei-hong |
| Institution: | ZHOU Man-hong,LI Jian-guo,HUANG Zu-min,ZHENG Ya-yu,ZHANG Yong-ping,XIAO Xue,WAN Wei-hong(Department of Emergency,the Affiliated Hospital of Zunyi Medical College,Zunyi Guizhou 563003,China) |
| Abstract: | Objective To investigate the protective effects of Rhizoma Paridis total saponins(RPTS)on the rats subjected to multiple trauma.Methods Seventy Wistar rats were randomly divided into three groups,and were made to the model in accordance with the standard of two-hit animal model induced by multiple fractures and lipopolysaccharide,except the blank control group.1 hour later,rats in RPTS groups were given Rhizoma Paridis total saponins by intragastric administration.6 hours later,the concentrations of TNF-α、I... |
| Keywords: | Rhizoma Paridis total saponins multiple trauma tumor necrosis factor alpha interleukin-1 beta interleukin-6 lipopolysaccharide Acute lung injury mortality rate |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |