Proton magnetic resonance spectroscopy reveals central neuroaxonal impairment in systemic sclerosis |
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| Authors: | Bertinotti Luca Mortilla Marzia Conforti Maria Letizia Colangelo Nicola Nacci Francesca Del Rosso Angela Fonda Claudio Casale Roberto Matucci-Cerinic Marco Pignone Alberto |
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| Affiliation: | Department of Internal Medicine, Section of Pheumatology, AOUC, University of Florence, Italy. |
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| Abstract: | OBJECTIVE:. Involvement of the central nervous system (CNS) in systemic sclerosis (SSc) is rare. Proton magnetic resonance spectroscopy (1H-MRS) assesses in vivo cerebral metabolites. We investigated the biochemical modifications of the CNS in SSc. METHODS: N-acetylaspartate/creatine ratio (NAA/Cr) and choline/creatine ratio (Cho/Cr) at right centrum semiovale (RCS) and at right basal ganglia (RBG) were evaluated by 1H-MRS in 12 patients with limited (lSSc) and 8 patients with diffuse SSc (dSSc) and 20 control subjects. RESULTS: With 1H-MRS, a significant reduction of NAA/Cr ratio at RBG (p < 0.02) and at RCS (p < 0.002) was detected in SSc patients. Cho/Cr ratio was increased (p < 0.02) in the RCS, but not in RBG. In patients with lSSc, a significant reduction of NAA/Cr was detected in RCS but not in RBG. CONCLUSION: Evidence of neuroaxonal damage strongly suggests the existence of CNS involvement in SSc. |
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