喉癌术后复发相关因素的临床分析

目的　探讨喉癌术后复发的相关因素和总结喉癌手术治疗失败的原因。方法　回顾性分析解放军总医院耳鼻咽喉科 1958～ 1999年喉癌手术病例 574例的临床资料。患者随访 3年以上 ,确诊复发 56例。对复发的相关因素包括年龄 ,性别 ,病史 ,住院时间 ,吸烟 ,病理分级 ,并发症 ,肿瘤分期 ,术式 ,输血 ,放射治疗 ,淋巴结转移等进行分析。结果　经统计学分析显示肿瘤T分期 (P =0 0 0 0 2 ) ,治疗方式 (P =0 0 0 17) ,输血 (P =0 0 0 0 1) ,放射治疗 (P =0 0 0 0 1) ,颈淋巴结转移 (P =0 0 2 2 8)与喉癌术后复发有显著意义。结论　肿瘤分期、术式、输血、放射治疗和淋巴结转移是引起喉癌术后复发的重要因素

Clinical analysis of relevant factors causing laryngeal cancer postoperative recurrence

Objective To investigate the clinical relevant factors causing laryngeal cancer postoperative recurrence and analysis the reasons of treatment failure Methods Totally, 574 cases of laryngeal cancer from 1958 to 1999 treated in ENT department of PLA general hospital were retrospectively reviewed All the patients were observed for 3 years postoperatively, and finally 56 cases of the recurrence were diagnosed We analyzed the factors possibly causing the recurrence including age, sex, history, time in hospital, smoke, grade of pathology, combination, tumor stage, transfusion, radiotherapy, operation manners and cervical lymph metastasis node grade Results By statistic analysis, tumor grade(P= 0 000 2), operation(P= 0 001 7), transfusion(P= 0 000 1), radiotherapy(P=0 000 1)and cervical lymphatic metastasis node grade(P= 0 022 8) have significant meaning with laryngeal cancer postoperative recurrence Conclusion Tumor grade, transfusion, radiotherapy, operation and cervical lymph metastasis node grade are main factors which may cause neoplasm postoperative recurring