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Tight glycaemic control: a prospective observational study of a computerised decision-supported intensive insulin therapy protocol |
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| Authors: | Rob Shulman Simon J Finney Caoimhe O'Sullivan Paul A Glynne Russell Greene |
| Affiliation: | (1) Pharmacy Department, University College London Hospitals NHS Trust, 235 Euston Road, London, NW1 2BU, UK;(2) Adult Intensive Care Unit, Royal Brompton Hospital, Sydney Street, London, SW3 6NP, UK;(3) Medical Statistics Group, Joint University College London Hospitals/University College London Biomedical Research Unit, 149 Tottenham Court Road, London, W1P 9LL, UK;(4) Critical Care Department, University College London Hospitals NHS Trust, 235 Euston Road, London, NW1 2BU, UK;(5) Pharmacy Department, School of Health and Biomedical Sciences, Kings College London, 150 Stamford Street, London, SR1 9NH, UK |
| Abstract: | IntroductionA single centre has reported that implementation of an intensive insulin protocol, aiming for tight glycaemic control (blood glucose 4.4 to 6.1 mmol/l), resulted in significant reduction in mortality in longer stay medical and surgical critically ill patients. Our aim was to determine the degree to which tight glycaemic control can be maintained using an intensive insulin therapy protocol with computerized decision support and to identify factors that may be associated with the degree of control. |
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