| 1-乙酰基-4-(4-羟基苯基)哌嗪的合成 |
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| 引用本文： | 李娴洁,李海波,田万里,徐正. 1-乙酰基-4-(4-羟基苯基)哌嗪的合成[J]. 华西药学杂志, 2005, 20(3): 243-244 |
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| 作者姓名： | 李娴洁 李海波 田万里 徐正 |
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| 作者单位： | 四川大学华西药学院,四川,成都,610041;四川大学华西药学院,四川,成都,610041;四川大学华西药学院,四川,成都,610041;四川大学华西药学院,四川,成都,610041 |
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| 摘 要： | 目的对抗真菌药酮康唑的重要中间体1-乙酰基-4-(4-羟基苯基)哌嗪的合成工艺进行研究。方法以六水合哌嗪和对氯硝基苯为原料合成目标化合物,并对工艺进行探索。结果得到目标化合物,总产率优于现行路线。结论该路线有希望用于工业化生产。
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| 关 键 词： | 1-乙酰基-4-(4-羟基苯基)哌嗪 合成工艺 抗真菌 |
| 文章编号： | 1006-0103(2005)03-0243-02 |
| 修稿时间： | 2004-12-01 |
The synthetical technology of 1-acetyl-4-(4-hydroxyphenyl)piperazine |
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| LI Xian-jie,LI Hai-bo,TIAN Wan-li,XU Zheng. The synthetical technology of 1-acetyl-4-(4-hydroxyphenyl)piperazine[J]. West China Journal of Pharmaceutical Sciences, 2005, 20(3): 243-244 |
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| Authors: | LI Xian-jie LI Hai-bo TIAN Wan-li XU Zheng |
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| Affiliation: | LI Xian-jie,LI Hai-bo,TIAN Wan-li,XU Zheng~* |
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| Abstract: | OBJECTIVE To study the synthetic technology of the important intermediate of antifungal drug ketoconazole,1-acetyl-4-~(4- hydroxyphenyl)piperazine. METHODS The title compound was synthesized from piperazine hexahydrate and p-chloronitrobenzene, and studied for its possibility of commereial use.RESULTS The title compound was obtained with yield excelled present route.CONCLUSION The route have a promise to be used in commercial production. |
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| Keywords: | 1-acetyl-4-(4-hydroxyphenyl)piperazine Synthetical technology Antifungal drug |
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