老年人脑白质病变的头颅MRI分型演变及其意义

脑白质病变在无残障的老年人头颅磁共振成像MRI上常可见到，但发生率各家报道差异很大。这种情况与研究设计以及脑白质病变评价方法的选择密切相关。既往大部分研究将其分为脑室旁和深部脑白质病变，但这种两分法不能很好反映脑白质病变的病理生理改变。新近有学者提出了更符合病理机制的分型方法：即脑室旁、近脑室、深部、近皮层脑白质病变。这种分型有助于提高脑白质病变研究的同质性，有助于及早进行针对性的病因干预。

The development of the classfication of white matter lesions on Magnetic Resonance Imaging in the elderly nondisaility people

White matter lesions （WMLs） is common on the MRI of the elderly non-disability people, and the incidence rates are various among different groups, depending on the the scales of the WHLs and the designs of researches. Most researches divide the WMLs into the the deep and periventricular WMLs, and the distinctions between periventricular white matter lesions and deep white matter lesions in terms of etiology are overlap. So recently there is a new subclassification of WMLs, considering of the pathophysiology of WMLs. The new categories is juxtaventricular, periventricular, deep white, and juxtacortical. The new classification of the WMLs may take advantage to conduce the heterogeneity of white matter lesion findings in future research.