| 广西85例肝癌患者庚型肝炎病毒感染的血清学研究 |
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| 引用本文： | 龙敏,杜绍财.广西85例肝癌患者庚型肝炎病毒感染的血清学研究[J].应用预防医学,1997,3(1):5-8. |
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| 作者姓名： | 龙敏 杜绍财 |
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| 作者单位： | 广西医科大学流行病学教研室!南宁530021(龙敏，邬质彬，徐国城，谢志春)，北京肝病研究所(杜绍财) |
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| 摘 要： | 对肝癌高发区的８５例患者血清采用套式ＰＣＲ方法检测认型肝炎病毒核糖核酸（ＨＧＶ－ＲＮＡ），并用相同方法检测了ＨＣＶ－ＲＮＡ；ＨＢＶ－ＤＮＡ则采用单次ＰＣＲ检测，阴性者再用套式ＰＣＲ证实。结果提示：８５例肝癌患者中，１１例患者可检出ＨＧＶＲＮＡ，占和的１２．９％，而ＨＣＶ－ＲＮＡ，ＨＢＶ－ＤＮＡ阳性者分别为１５例及６８例，占１７．６％和８０％。初步证明文本部分肝癌病人血清中存在ＧＶ感染，作者认为：Ｈ
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| 关 键 词： | 肝癌 庚型肝炎病毒 感染 血清学 |
A serological study on hepatitis G virus(HGV)infection in patients with hepat ocellular carcinoma. |
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| Long Min,Wu ZhiBin,Du ShaoCai,et al..A serological study on hepatitis G virus(HGV)infection in patients with hepat ocellular carcinoma.[J].Journal of Applied Preventive Medicine,1997,3(1):5-8. |
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| Authors: | Long Min Wu ZhiBin Du ShaoCai |
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| Institution: | Long Min,Wu ZhiBin,Du ShaoCai,et al.Department of Epidemiology GuangXi Medical University |
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| Abstract: | In order to study a new hepatitis virus(HGV) infection and its role in patients with hepatocellular carcinoma in GuangXi which is a hepatocellular carcinoma endemic area.HGV-RNA,HCV-RNA,HBV-DNA in the sera of 85 patients with hepatocellular carcinoma from that area were detected using nested-PCR methods(HBV-DNA was firstly detected by single-PCR then the negative were confirmed by nested-PCR).The results showed that 11 out of 85 patients(12.9%)were seropositive for HGV-RNA,and the seropositive rate for HCV-RNA,HBV-DNA were 17.6%(15/85)and 80%(68/85) respectively among these patients.The preliminary conclusions are as follows:There are HGV infection in sera of some patients with hepatocellular carcinoma.Of the factors in hepatocellular carcinoma occurrence,HBV infection still plays a major role,and HCV is less important in the development of HCC compared with HBV.The role mechanism of HGV infection in hepatocellular carcinoma await further study. |
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| Keywords: | Patients with hepatocellular carcinoma HGV infection Polymerase chain reaction(nested-PCR) |
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