| 埃索美拉唑与奥美拉唑三联疗法治疗十二指肠球部溃疡的成本—效果分析 |
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| 引用本文： | 李振山,尹玲,王少华,王彦辉. 埃索美拉唑与奥美拉唑三联疗法治疗十二指肠球部溃疡的成本—效果分析[J]. 泰山医学院学报, 2009, 30(12) |
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| 作者姓名： | 李振山 尹玲 王少华 王彦辉 |
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| 作者单位： | 1. 泰山医学院附属医院,山东,泰安271000;山东大学药学院,山东,济南250012
2. 泰山医学院附属医院,山东,泰安271000 |
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| 摘 要： | 目的对埃索美拉唑与奥美拉唑三联疗法治疗Hp阳性的十二指肠球部溃疡的成本-效果分析。方法将83例胃幽门螺杆菌(Hp)阳性的十二指肠球部溃疡患者随机分为两组:埃索美拉唑三联组(A组,n=46)和奥美拉唑三联组(B组,n=37),分别给予埃索美拉唑和奥美拉唑为主的三联疗法,疗程结束后4周复查胃镜并检测Hp,观察两组患者十二指肠球部溃疡的愈合率和Hp的根除率,同时于用药第1,2,3,7d观察临床症状的改善情况,并运用药物经济学成本-效果分析法对两组治疗方案进行分析。结果80例患者完成试验,埃索美拉唑三联组的十二指肠球部溃疡愈合率为90.9%(40/44),Hp根除率为84.1%(37/44);奥美拉唑三联组的十二指肠球部溃疡愈合率为88.9%(32/36),Hp根除率为80.6%(29/36)。经比较两组溃疡愈合率和Hp根除率无显著性差异(P>0.05)。A组第1天和第2天症状缓解率分别为38.6%和63.6%,高于B组的13.9%和36.1%(P<0.05)。不良反应发生率分别为4.55%和5.56%。结论从药物经济学角度看,在埃索美拉唑和奥美拉唑三联疗法治疗十二指肠球部溃疡中,埃索美拉唑三联疗法较佳。
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| 关 键 词： | 成本效果分析 埃索美拉唑 奥美拉唑 十二指肠球部溃疡 三联疗法. |
Cost-effectiveness analysis of esomeprazole-based and omeprazole-based triple therapeutic schemes for duodenal ball department ulcer |
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| LI Zhen-shan,YIN Ling,WANG Shao-hua,WANG Yan-hui. Cost-effectiveness analysis of esomeprazole-based and omeprazole-based triple therapeutic schemes for duodenal ball department ulcer[J]. Journal of Taishan Medical College, 2009, 30(12) |
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| Authors: | LI Zhen-shan YIN Ling WANG Shao-hua WANG Yan-hui |
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| Affiliation: | (The Affiliated Hospital of Taishan Medical College; Taian 271000; China); |
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| Abstract: | Objective: To carry out the Cost-effectiveness Analysis of Esomeprazole-based and Omeprazole-based triple Therapeutic Schemes for Duodenum ball department Ulcer.Methors: 83 Patients were assigned to receive one of the two regimens:group A(Esoprazole-based) or group B(Omeprazole-based).The relives of the symptoms were also evaluated on 1st,2ed,3rd,7thday in the treatment.Using the method of Cost-effectiveness analysis to evaluate two therapeutic schemes.Results: 80 patients completed the trial.The ulcer heal... |
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| Keywords: | cost-effectiveness analysis esomeprazole omeprazole duodenal ulcer triple therapy |
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