Presepsyna (rozpuszczalny podtyp CD14-ST) jako diagnostyczny biomarker posocznicy u noworodków |
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Authors: | Magdalena Kwiatkowska-Gruca Jakub Behrendt Alicja Sonsala Dominika Wiśniewska-Ulfik Bogdan Mazur Urszula Godula-Stuglik |
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Institution: | 1 Klinika Intensywnej Terapii i Patologii Noworodka Katedry Pediatrii SUM w Katowicach, Zabrze, Polska;2 Studium Doktoranckie Wydzia?u Lekarskiego z Oddzia?em Lekarsko-Dentystycznym w Zabrzu, SUM w Katowicach, Zabrze, Polska;3 Katedra i Zak?ad Mikrobiologii i Immunologii Wydzia?u Lekarskiego z Oddzia?em Lekarsko-Dentystycznym w Zabrzu SUM w Katowicach, Zabrze, Polska |
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Abstract: | BackgroundDetermination of sCD14-ST (presepsin) concentration as a marker for infections in newborns was not performed till now.Aim1. Assessment of blood presepsin concentration in newborns, including their sex, fetal maturity, birth weight, early-onset sepsis. 2. Determination of correlation between presepsin value and CRP, procalcitonin concentrations and some hematological parameters.Material and methodsThe study comprised 45 newborns, among them 27 septic and 18 without infection, but with perinatal risk factors or symptoms suggesting infection, in which by rapid chemiluminescent enzyme immunoassay, using Pathfast TM analyser from Mitsubishi Kagaku Iatron, sCD14-ST concentration in whole blood was measured.ResultsThe mean presepsin concentration in septic newborns (1772 ± 1009 pg/ml) was significantly higher than in group without infection (556 ± 158). Positive correlations between sCD14-ST and CRP, procalcitonin concentrations and negative correlations between the value of presepsin and Ht, Hb, platelet count, birth weight and fetal maturity were noted.Conclusions1. In newborns with early-onset sepsis, independently of their sex, birth weight, fetal maturity, significant increase presepsin concentration, correlating with increase of CRP and procalcitonin values and with decrease of platelet count, Hb and Ht. 2. Measurement of presepsin concentration in neonatal whole blood may be usefulness in diagnosis of early-onset sepsis. |
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Keywords: | presepsyna noworodek sepsa |
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