丹白颗粒治疗湿热瘀结型盆腔炎后遗症的临床观察

目的：探讨丹白颗粒对湿热瘀结型盆腔炎后遗症的疗效及安全性。方法：选取2020年12月至2021年12月北京中医药大学东直门医院、山东省中医院等妇科门诊收治的湿热瘀结型盆腔炎后遗症患者120例作为研究对象，采用随机数字表法将受试者按照1：1的比例分组，经病例脱落后，最终纳入观察组（n=58）和对照组（n=59），共计117例。对照组采用盐酸左氧氟沙星胶囊联合甲硝唑片口服治疗，观察组在对照组的基础上加用丹白颗粒口服，2组均治疗2周。比较2组的临床疗效、视觉模拟评分法（VAS）评分、健康调查量表36（SF-36）、C反应蛋白（CRP）、红细胞沉降率（ESR）、阴道分泌物清洁度、下腹痛消失时间、带下恢复正常时间及不良事件发生率。结果：观察组的总有效率93.10%（54/58）明显高于对照组的79.66%（37/59）（P<0.05）。治疗后2组患者下腹疼痛VAS评分、下腹痛及白带增多的症状消失时间及CRP、ESR均明显降低，SF-36量表评分明显升高（P<0.05），阴道分泌物清洁度明显改善（P<0.05）。观察组各项指标均优于对照组（均P<0.05）。2组不良反应的发生率差异无统计学意义（P>0.05)。结论：在西医常规治疗的基础上联合丹白颗粒可提高湿热瘀结证盆腔炎后遗症的疗效，进一步减轻患者的症状体征和疼痛程度，改善阴道分泌物清洁度，降低炎症指标水平，提高患者生命质量，值得临床借鉴应用。

Clinical Observation of Danbai Granules in Treating Sequelae of Pelvic Inflammatory Disease of Dampness-heat Stasis Type

To investigate the clinical efficacy and safety of Danbai Granules in treating the sequelae of pelvic inflammatory disease of dampness-heat and stasis type.Methods:A total of 120 patients with sequelae of pelvic inflammatory disease treated in the Department of Gynaecology of Dongzhimen Hospital of Beijing University of Chinese Medicine and Shandong Provincial Hospital of Traditional Chinese Medicine from December 2020 to December 2021 were selected.Considering patient dropout,117 cases were finally included and divided into a study group(n=58) and a control group(n=59) according to the random number table method.The control group received conventional western treatment(levofloxacin hydrochloride capsules and metronidazole tablets,oral),while the study group took Danbai Granules orally on the basis of the control group.After treatment of 2 weeks,the clinical efficacy,visual analogue scale(VAS) score,36-Item Short Form Health Survey questionnaire(SF-36) score,C-reactive protein(CRP),erythrocyte subsidence rate(ESR),vaginal cleanliness,time of abdominal pain and leucorrhea disappearance,and incidence of adverse events were compared between the two groups.Results:The total effective rate of the study group(93.10%,54/58) was higher than that(79.66%,37/59) of the control group(P<0.05).After treatment,the VAS score,time of abdominal pain and leucorrhea disappearance,CRP and ESR were decreased,and SF-36 score were increased in the two groups(P<0.05); additionally,the vaginal cleanliness was improved(P<0.05).The study group was better than the control group in each index(P<0.05).There was no significant difference in incidence of adverse reactions between the two group(P<0.05).Conclusion:The clinical efficacy of Danbai Granules combined with conventional western treatment was significant in treating the sequelae of pelvic inflammatory disease of dampness-heat stasis type,which could reduce the pain degree,alleviate symptoms,improve vaginal cleanness,decrease inflammatory factor levels and improve quality of life of patients,which was worthy for clinical application.