围产期孕妇生殖道分泌物无乳链球菌的分布及耐药分析

目的 分析围产期孕妇生殖道分泌物中无乳链球菌的分布情况及耐药性,为临床预防和合理使用抗生素提供依据.方法 对2016年1月-2019年12月本院产科围产期孕妇送检的24244例宫颈分泌物进行细菌培养鉴定和药敏试验,对分离出的无乳链球菌进行药敏分析.结果 从24244例围产期孕妇宫颈分泌物中分离细菌764例,阳性率为3....

Analysis of distribution and drug resistance of Streptococcus agalactiae in reproductive tract secretions of perinatal pregnant women

Objective To analyze the colonization and drug resistance of Streptococcus agalactiae in the genital tract secretions of pregnant women during perinatal period,and to provide the basis for clinical prevention and rational use of antibiotics.Methods A total of 24244 cases of cervical secretions submitted by perinatal pregnant women in our hospital were identified by bacterial culture and drug sensitivity test from January 2016 to December 2019,and drug sensitivity tests was conducted on the isolated streptococcus agalactiae.Results 764 cases of bacteria were isolated from the cervical secretions of 24244 perinatal pregnant women,with a positive rate of 3.15%,of which 81.6%were Gram-positive bacteria and Streptococcus agalactiae(73.0%)were the main bacteria.Gram-negative bacteria accounted for 18.4%,and the main bacteria were Escherichia coli(14.0%),Klebsiella pneumoniae(1.4%)and Enterobacter pneumoniae(1.0%).The sensitivity rate of Streptococcus agalactiae to penicillin、cefazolinwas、cefuroxiome、Ampicillin、Vancomycin、teicoplanin and Linezolid were 100%;The resistance rate of Clindamycin and Tetracyclnie were above 80%.Conclusions Streptococcus agalactiae were mainly found in the reproductive tract of perinatal pregnant women in this area.Penicillin can be the first choice of prophylactic drugs for Streptococcus agalactiae,and appropriate antibiotics can be selected for people allergic to penicillin and other bacterial infections according to the results of drug sensitivity.Bacterial culture of cervical secretions during perinatal period is of great significance for clinicians to carry out antiinfection control in time and reduce mother-to-child transmission.