百令胶囊辅助治疗糖尿病肾病的Meta分析

目的 系统评价百令胶囊辅助治疗糖尿病肾病的有效性和安全性.方法 计算机检索PubMed、中国学术期刊全文数据库(CNKI)、维普中文期刊全文数据库(VIP)、中国生物医学文献数据库(CBM)和万方数据库中有关百令胶囊单独或联合其他药物治疗糖尿病肾病的临床随机对照试验(RCT),检索时间从各数据库建库至2020年1月,按...

Meta-analysis of Bailing Capsule in treatment of diabetic kidney disease

Objective To systematically evaluate the efficacy and safety of Bailing Capsule for treating diabetic kidney disease(DKD).Methods Randomized controlled trials of Bailing Capsule in the treatment of DKD was collected by searching PubMed,CNKI,VIP,CBM and Wanfang databases by computer from inception to January 2020.Extract the information and evaluate the quality of the included literature.RevMan 5.3 software was used for Meta-analysis.Results A total of 12 studies involving 1011 patients were included into the study.The results of meta-analysis showed that Bailing Capsule in the treatment of DKD can improve total effective rate[OR=5.04,95%CI=(3.16,8.03),P<0.00001]and decrease urinary albumin excretion rate[SMD=-1.95,95%CI=(-2.74,-1.17),P<0.00001],serum creatinine[SMD=-2.14,95%CI=(-3.57,-0.71),P=0.003],24-hour urine protein[SMD=-1.56,95%CI=(-2.45,-0.76),P=0.0001]and fasting blood glucose[SMD=-0.52,95%CI=(-0.59,-0.47),P<0.00001].No adverse reactions were reported in all the included literatures.Conclusion Bailing Capsule have certain effect to treat DKD and the safety is good,which is worthy of being learned in clinic.However,there are some deficiencies in this study,so more highquality and large sample clinical studies are still needed to further confirm.