1例药源性伪膜性肠炎患者的临床药学监护

目的 报告1例腹痛不伴有腹泻症状的伪膜性肠炎患者的临床治疗与药学监护，以提示临床提高警惕。方法 临床药师通过参与诊疗，获知患者的疾病史与药物治疗史，结合肠镜寻找病因，提出建议，与医师协同合作，提高医疗质量。结果 经过调查分析其药物治疗经过，最可能的病因是广谱抗菌药物、质子泵抑制剂的联合使用导致艰难梭菌感染，为药品不良反应。结论 抗菌药物及质子泵抑制剂的不合理使用造成严重艰难梭菌感染，值得引起重视。对于长时间、多品种使用抗菌药物且无腹泻症状的伪膜性肠炎更应予以关注。

Pharmaceutical Care of a Patient with Drug-induced Pseudomembranous Enteritis

Tablets have always been an important preparation in clinical application, but the development and design mode, quality evaluation technology and production quality control mode of tablets can hardly meet the current demand. This paper summarizes the application of multivariable data analysis technology, artificial neural network technology and 3D printing technology in the design and development of tablets to meet the rapid preparation and personalized production of tablets. It also discusses the near infrared optical technology, terahertz pulse imaging technology, nuclear magnetic resonance imaging technology and other new detection technologies in the quality evaluation of tablets. Compared with the traditional detection technology, the new detection technology is efficient, sensitive and convenient. At the same time, it follows the concept that quality originates from design in establishing the quality control strategy for the development and production of tablets. It is of great significance to improve the safety and effectiveness of tablets as well as the development and production of tablets.