异位错构瘤性胸腺瘤1例及文献复习

目的探讨异位错构瘤性胸腺瘤(EHT)的临床及病理特征。方法复习1例EHT患者的临床病史、肿瘤组织的病理形态和免疫表型及相关文献。结果患者男性,56岁,以左胸锁关节下方皮下肿块为主要表现。肿瘤包膜完整,切面以灰白色实性为主。镜下表现复杂,以束状及平行排列的梭形细胞为主,混合有上皮成分及成熟的脂肪细胞等。瘤细胞均不具异型性,也缺乏坏死。免疫组化显示梭形细胞CK阳性,灶状细胞MSA阳性,S-100蛋白、desm in、vim entin和CD34均呈阴性。结论EHT有独特的发病部位和形态学表现,对梭形细胞上皮本质的认识是正确诊断的关键。

Ectopic hamartomatous thymoma: a case report and review of literature

Purpose To study the clinico-pathological characteristics of ectopic hamartomatous thymoma.Methods With review of the literature,the clinical history,histopathological changes and immunohistochemical expression were investigated and reviewed in one case of ectopic hamartomatous thymoma.Results A 56-year-old man presented with a subcutaneous mass adjacent to the left sternoclavicular joint region,which had predominant spindle cells,a small number of epithelial component and mature adipose tissue; the varied components lacked atypia and necrosis.In immunohistochemistry,both the spindle cell and epithelial components stained diffusely and strongly for cytokeratin,a proportion of the spindle cells were immunoreactive for MSA.Staining for S-100 protein,desmin,vimentin and CD34 was negative in spindle cells as well as epithelial cells.Conclusions Ectopic hamartomatous thymoma has a unique histological appearance as well as sites of involvement.Well recognition of the spindle cell as epithelial nature is a key to correctly diagnose this rare tumor.