| 黄连解毒汤的抗血栓作用研究 |
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| 引用本文： | 付晓春,王敏伟.黄连解毒汤的抗血栓作用研究[J].沈阳药科大学学报,2001,18(6):425-427. |
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| 作者姓名： | 付晓春 王敏伟 |
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| 作者单位： | 沈阳药科大学药学院 |
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| 摘 要： | 黄连解毒汤提取物 4 5 0、90 0、1 80 0mg/kg ,连续灌胃 3d,末次给药 1h后能显著延长小鼠体外凝血时间。家兔灌胃黄连解毒汤 1 5 0、30 0、6 0 0mg/kg,连续给药 3d,末次给药 1h后能明显延长血浆凝血酶原时间、白陶土活化部分凝血活酶时间及凝血酶时间 ,并能显著抑制ADP引起的血小板聚集。实验结果表明 ,黄连解毒汤具有明显的抗血栓形成作用。
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| 关 键 词： | 黄连解毒汤(HLJDD) 复方丹参片(FFDST) 抗血栓 血小板聚集 凝血时间 |
| 文章编号： | 1006-2858(2001)06-0425-03 |
| 修稿时间： | 2001年4月16日 |
Research on antithrombotic effects of Huanglian Jiedu Decoction |
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| FU Xiao chun,WANG Min wei.Research on antithrombotic effects of Huanglian Jiedu Decoction[J].Journal of Shenyang Pharmaceutical University,2001,18(6):425-427. |
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| Authors: | FU Xiao chun WANG Min wei |
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| Abstract: | The antithrombotic effect of Huandglian Jiedu Decoction (HLJDD) was studied in this paper.The thrombin time(TT),prothrombin time(PT),KPTT in rabbits and clotting time in mice were prolonged significintly.The platelet aggregation induced by ADP in the rabbits was inhibited.All those results suggested that HLJDD could refrain the formation of artery thrombus,the euglobulin lysis time (ELT) was not shortened,the weight of blood clotting in mice was not lightened,and those results showed that HLJDD can not dissolve arteris thrombus in the rabbits. |
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| Keywords: | Huanglian Jiedu Decoction Fufang Danshen Tablets antithrombotic platelet aggregation clotting time |
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