立体定向放射治疗肺癌的临床研究

目的探讨立体定向放射治疗肺癌的近期疗效。方法采用深圳OUR-XK治疗仪治疗152例肺癌患者,5~8Gy/次,隔日1次,肿瘤靶区总剂量在55~78Gy。结果治疗结束1~6月后复查CT,肿块完全消失(CR)40例(26.3%)、部分缓解(PR)92例(60.5%)、无变化(NC)+进展(PD)20例(13.2%),总有效率86.8%。57例肿瘤体积≤30cm3者有效率为98.25%,95例肿瘤体积>30cm3者有效率为80.0%,两者比较差异有显著性(P<0.005)。结论立体定向放射治疗肺癌近期疗效显著,随着临床经验的不断积累,这项技术必将在肺癌的治疗中占有重要地位。

Stereotactic radiotherapy for lung carcinoma

Objective∶ To assess the response of fractional stereotactic radiotherapy(SRT)for lung cancer. Methods:152 lung cancer patients were treated with SRT which was given every other day and 5 to 8 Gy per fraction with the total doses from 55 to 78 Gy. Results: All the patients were reexamined in 1～6months after treatment.The mass disappeared in 40 patients(26.3%), shrank over 1/2 in 92 patients(60.5%),and the other 20 cases didn’t show obvious change (13.2%)。The overall response rate(CR+PR) was 86.8% for the primary tumor. An overall response rate was 98.25% for tumor volume ≤30 cm3,and was 80.0% for tumor volume>30 cm3,showing significant difference(P<0.005).Conclusion: Stereotactic radiotherapy provides excellent lesion control in lung cancer. It will become an important therapeutic method in the combined treatment of lung cancer.