| 滋补肝肾通络解毒中药对帕金森病大鼠旋转行为的影响 |
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| 引用本文： | 何建成,袁灿兴,卫洪昌,陈汝兴. 滋补肝肾通络解毒中药对帕金森病大鼠旋转行为的影响[J]. 中国组织工程研究与临床康复, 2003, 7(25): 3456-3457 |
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| 作者姓名： | 何建成 袁灿兴 卫洪昌 陈汝兴 |
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| 作者单位： | 1. 上海中医药大学诊断学教研室,上海市,200032
2. 上海中医药大学附属龙华医院神经内科,上海市,200032 |
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| 基金项目： | 上海市教委基金资助(98C08)~~ |
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| 摘 要： | 目的:阐明滋补肝肾通络解毒中药治疗帕金森病的作用机制。方法:采用6-羟基多巴胺(6-hydroxydopamine,6-OHDA)注射于脑右侧黑质造成偏侧帕金森病(Parkinson'sdisease,PD)模型,并用滋补肝肾通络解毒中药进行治疗,同时设立正常对照组、假手术组,观察中药对PD大鼠旋转行为的影响。结果:正常对照组、假手术组在治疗前后均未发现动物有旋转行为。而模型组和中药组在治疗前两组的旋转圈数分别为269±99和253±50,差异无显著性意义(t=0.649,P>0.05);治疗后两组的旋转圈数分别为263±87和164±35,差异有显著性意义(t=4.748,P<0.01)。其中,与模型组比较,中药组的旋转圈数明显减少(t=9.544,P<0.01)。结论:滋补肝肾通络解毒中药能明显改善模型大鼠的旋转行为。
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| 关 键 词： | 植物 药用 帕金森病 神经行为学表现 大鼠 Wister |
| 文章编号： | 1671-5926(2003)25-3456-02 |
| 修稿时间： | 2003-05-10 |
Effect of Chinese herbs of nourishing liver ＆ kidney, clearing collaterals and detoxification on rotational behavior of rats with Parkinson''s disease |
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| Jian-Cheng He,Can-Xing Yuan,Hong-Chang Wei,Ru-Xing ChenJian-Cheng He,Hong-Chang Wei,Teaching and Research Section of Diagnosis,Shang hai University of Traditional Chinese Medicine,Shanghai ,China Can-Xing Yuan,Ru-Xing Chen. Effect of Chinese herbs of nourishing liver ＆ kidney, clearing collaterals and detoxification on rotational behavior of rats with Parkinson''s disease[J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2003, 7(25): 3456-3457 |
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| Authors: | Jian-Cheng He Can-Xing Yuan Hong-Chang Wei Ru-Xing ChenJian-Cheng He Hong-Chang Wei Teaching Research Section of Diagnosis Shang hai University of Traditional Chinese Medicine Shanghai China Can-Xing Yuan Ru-Xing Chen |
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| Affiliation: | Jian-Cheng He,Can-Xing Yuan,Hong-Chang Wei,Ru-Xing ChenJian-Cheng He,Hong-Chang Wei,Teaching and Research Section of Diagnosis,Shang hai University of Traditional Chinese Medicine,Shanghai 200032,China Can-Xing Yuan,Ru-Xing Chen,Department of Neurology,Longhua Hospital,Shangh ai University of Traditional Chinese Medicine,Shanghai 200032,China |
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| Abstract: | |
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| Keywords: | Chinese herbs of nourishing liver and kidney clearing collaterals and detoxification significantly improve the rotational behavior of model rats. |
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