882例健康体检妇女HPV感染状况分析

目的了解健康体检女性人乳头瘤病毒（HPV）感染型别分布及年龄特点,为宫颈癌防治提供理论依据。方法采用凯普医用核酸分子快速导流杂交基因芯片技术,对882例健康体检妇女进行生殖道21种HPV亚型感染筛查。结果 882例体检人群HPV总感染率为16.8%,21种亚型中有15种被检出,感染率最高的型别是HPV16,其他常见型别依次为52型、58型、53型、CP8304型、18型、68型、33型和66型,高危感染率为97.3%,低危感染率为2.7%,单一感染率为85.1%,多重感染率为14.9%。882例HPV感染率各年龄段检出率差异无统计学意义（P〉0.05）。结论甘肃地区健康体检女性HPV感染有相当比例,尤其是高危型,亚型分布且有一定区域性,对体检女性进行HPV分型检测有重要意义。

Analysis on Human Papilloma Vius Infection Status in 882 Women Who Underwent Health Checkup

OBJECTIVE To evaluate prevalence of human papilloma virus（HPV）infection and genotypes of the virus in 882 women who underwent health checkup. METHODS A total of 882 outpatient were checked for 21 HPV DNA types by DNA flow-through hybridization genotyping technique（Hybrimx）. RESULTS The total infection rate of HPV was 16.8%, 15 genotypes were found by Hybrimx in total 21 HPV genotypes, the most common HPV genotype was HPV-16, followed by 52, 58, 53, CP8304, 18, 68, 33and 66. The prevalence of high-risk and lowrisk HPV infection was 84.1% and 10.6%, respectively. The single and multiple HPV infection was 97.3% and 2.7%, respectively. The single and multiple HPV infection was 85.1% and 14.9%, respectively. There was no significant difference in the HPV-positive rates among each age group（P〉0.05）. CONCLUSION Gansu was a high percentage of HPV infection rate in women health checkup, especially in high-risk type, and also have its own regional character. The HPV types had important significanced in women who took health examination.