Patient-specific transfusion-related acute lung injury |
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Authors: | Muniz M Sheldon S Schuller R M Young N S Klein H G Leitman S F Stroncek D F |
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Affiliation: | Department of Transfusion Medicine Clinical Center, National Institutes of Health, Bethesda, MD 20892-1184, USA. |
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Abstract: | Transfusion-related acute lung injury (TRALI) is one of the leading causes of transfusion-associated mortality. The inadvertent transfusion of neutrophil antibodies can cause pulmonary transfusion reactions and TRALI. However, not all patients transfused with neutrophil antibodies experience transfusion reactions. A 22-year-old man with severe aplastic anaemia (SAA) experienced TRALI after a platelet transfusion. The donor was found to be alloimmunized to human neutrophil antigen (HNA)-3a, an antigen expressed by neutrophils from approximately 90% of Caucasians. Eleven other platelet components from this donor were transfused prior to this event and two caused reactions: one chills and one TRALI. Both episodes of TRALI occurred in the same male patient with SAA. The fact that one patient experienced TRALI following both exposures to anti-HNA-3a from the same donor whereas nine other recipients did not adds evidence to the observation that patient factors make a significant contribution to neutrophil antibody-mediated transfusion reactions. |
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Keywords: | neutrophil antibodies platelet platelet transfusions transfusion reactions transfusion-related acute lung injury |
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