| 青石棉染尘大鼠血,肺中SOD,LPO变化的研究 |
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| 引用本文： | 杨青,罗素琼.青石棉染尘大鼠血,肺中SOD,LPO变化的研究[J].中国公共卫生学报,1995,14(6):358-360. |
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| 作者姓名： | 杨青 罗素琼 |
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| 作者单位： | 华西医科大学尘肺研究室 |
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| 基金项目： | 国家教委高校博士点专项科研基金,CMB资助 |
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| 摘 要： | 对大鼠经气管内注入青石棉纤维，在染尘后９０、１８０、２７０、３６０和５４０天动态观察血和肺中超氧化物歧化酶（ＳＯＤ）、脂质过氧化物（ＬＰＯ）及ＳＯＤ／ＬＰＯ比值的变化。结果表明，青石棉可诱发大鼠血和肺组织中自由基反应增强，ＳＯＤ活性降低，脂质过氧化反应增高，ＬＰＯ含量升高，抗氧化能力降低，ＳＯＤ／ＬＰＯ比值降低，体内抗氧化和脂质过氧化平衡失调。
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| 关 键 词： | 青石棉 超氧化物歧化酶 脂质过氧化物 |
study of SOD and LPO in Blood and Lung of Rats Injected Intrachacheally with Crocidolite |
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| Authors: | Yang Qing |
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| Institution: | Yang Qing,et al., |
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| Abstract: | Wistar rats,weighing 180-240g were used. The animal were at random divided into control group and crocidolite group.Samples of blood and lung tissue of rats were collected in 90,180, 270, 360 and 540 days after the third time of injection.The SOD activity and level of LPO were measured. The results indicated that crocidolite could cause the imbalance of antionxidant and oxidant |
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| Keywords: | crocidolite SOD LPO |
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