| 细胞凋亡过程中c-fos、p53和c-myc基因的表达 |
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| 引用本文： | 胡杰英,赵书民,陈奎生. 细胞凋亡过程中c-fos、p53和c-myc基因的表达[J]. 肿瘤基础与临床, 1997, 0(6) |
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| 作者姓名： | 胡杰英 赵书民 陈奎生 |
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| 作者单位： | 河南省肿瘤研究所(胡杰英，赵书民)，河南医科大学分子细胞生物学研究中心(陈奎生) |
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| 摘 要： | 本文主要研究细胞凋亡过程中c－fos、p53和c－myc等基因的表达。方法：经8－Br－cAMP诱导人食管癌Eca－109细胞调亡，应用原位来交技术对c－fos、p53和c－myc基因的表达进行检测。结果：经过诱导的试验组和不经诱导的对照组c－fos、p53和c－myc基因的表达差异有显著性（P＜0．001）。结论：提示这些基因在细胞凋亡的发生发展过程中起着重要的作用。
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| 关 键 词： | 细胞凋亡 诱导 原位杂交 c－fos、p53和c－myc基因 |
Expression of c - fos, c - myc and p53 Gene in Apoptosis |
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| Hu Jieying, Zhao Shumin, Chen Kuisheng. Expression of c - fos, c - myc and p53 Gene in Apoptosis[J]. journal of basic and clinical oncology, 1997, 0(6) |
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| Authors: | Hu Jieying Zhao Shumin Chen Kuisheng |
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| Abstract: | Expressions of c - for,c - myc and P53 gene in apoptosis are studied in this report.Methed:Human Eca-109 cells were induced to apoptosis with 8 - Br- cAMP and hybridization in situ was used to detect these genes' expression in apoptosis.Results:The results showed that the expression of c - fos,c - myc and p53 gene in induced experimental groups and in non - induced control groups had marked difference (P<0.001) .Conlussions:It is suggested that c- fos,c - myc and P53 genes Play an important part in the occurrence and development of apoptosis. |
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| Keywords: | apoptosis induce hybridization in situ c-fos c-myc p53 gene |
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