Live donor study – implications of kidney donation on cardiovascular risk with a focus on lipid parameters including lipoprotein a |
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| Authors: | Brian Doucet Karam Kostner Omar Kaiser Carmel Hawley Nicole Isbel |
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| Affiliation: | 1. Department of Cardiology, Mater Misericordiae Hospital, Brisbane, Queensland, Australia;2. School of Medicine, University of Queensland, Brisbane, Queensland, Australia;3. Department of Nephrology, Princess Alexandra Hospital, Brisbane, Queensland, Australia;4. Translational Research Institute, Brisbane, Queensland, Australia;5. Australasian Kidney Trials Network, University of Queensland, Brisbane, Queensland, Australia |
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| Abstract: | In this prospective observational cohort study, we evaluate the change in cardiovascular risk parameters, with a focus on lipids, in live kidney donors 1 year post donation. Body mass index, systolic/diastolic blood pressure, kidney function (chromium‐51 ethylenediaminetetraacetic acid estimated glomerular filtration) and lipid parameters were measured at baseline and 1 year. Data on 87 live kidney donors were collected. Body mass index increased from 26.5 ± 2.7 pre to 27.4 ± 3.0 kg/m2 post donation (p < 0.0001). Chromium‐51 ethylenediaminetetraacetic acid estimated glomerular filtration decreased from 111.8 ± 20.0 pre to 72.1 ± 13.1 mL/min/1.73 m2 post donation (p < 0.0001). Serum triglyceride levels increased from 0.8 (interquartile range 0.6–1.3) pre to 1.0 mmol/L (interquartile range 0.7–1.6) post donation (p = 0.0004). Statin use increased from 11.5% pre to 21% post donation (p < 0.005). Low‐density lipoprotein remained stable, and other lipids (high‐density lipoprotein, apolipoprotein B and lipoprotein a) did not change post donation. |
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| Keywords: | cardiovascular risk lipids living donor transplantation Lp(a) transplantation |
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