急性脑血管病患者外周血、脑脊液白细胞计数的动态研究

目的：探讨白细胞增多在急性脑血管病（ＡＣＶＤ）发病中的作用。方法：对１５０例ＡＣＶＤ患者外周血和脑脊液（ＣＳＦ）白细胞计数进行了动态观察。结果：ＡＣＶＤ患者急性期外周血和ＣＳＦ中白细胞计数均显著高于对照组（Ｐ均＜０．０１）；外周血和ＣＳＦ中白细胞计数在病后４８小时开始升高，７２小时达高峰；随着病情改善，白细胞计数逐渐恢复正常；且白细胞计数与ＡＣＶＤ患者的病情严重程度及预后存在一定相关性（ｒ＝０．３９５，Ｐ＜０．０１）；病变部位不同，白细胞计数的变化明显不同〔基底节出血（或梗死）＞脑叶出血（或梗死）＞其它部位出血，Ｐ＜０．０１或Ｐ＜０．０５〕。结论：外周血和ＣＳＦ中的白细胞计数可作为判断ＡＣＶＤ病情、病变部位及预后的辅助指标；白细胞参与了ＡＣＶＤ的病理生理过程，并在其发病和脑组织损伤中起重要作用。

Dynamic study on leucocyte count of peripheral blood and cerebral spinal fluid in patients with acute cerebral vascular disease

Objective:To investigate the role of leucocytosis in pathogenesis of acute cerebral vascular disease (ACVD).Methods:The leucocyte count in peripheral blood and cerebral spinal fluid (CSF) in 150 cases of ACVD were observed dynamically.Results:In acute phase of ACVD,the leucocyte count in blood and CSF were higher obviously than those in control group (both P <0 01);it raised at 48 hours and reached peak value at 72 hours after ACVD onset;leucocyte count return to normal value gradually with improvement of disease;there had a relationship between leucocyte count in blood and CSF and ACVD severity and prognosis ( r =0 395, P <0 01);the changes in leucocyte count were different obviously in several position basal ganglia hemorrhage (or infarction)>cerebral lobe hemorrhage (or infarction)>other position, P <0 01 or P <0 05 .Conclusions:There was an reference index of leucocyte count in blood and CSF to judging the ACVD condition,damage position and prognosis;leucocyte parti cipates pathophysiologic process of ACVD and plays important role in cerebral tissue damage.