| 还少丹的脑保护机制研究 |
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| 引用本文： | 左萍萍,刘娜,雒蓬轶,沈琦,唐利军,胡韶毅. 还少丹的脑保护机制研究[J]. 中国中西医结合杂志, 1997, 17(7): 420-422 |
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| 作者姓名： | 左萍萍 刘娜 雒蓬轶 沈琦 唐利军 胡韶毅 |
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| 作者单位： | 中国医学科学院基础医学研究所 |
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| 摘 要： | 目的：为探讨中药古成方“还少丹”的脑保护机制，观察了该药对脑兴奋性损伤模型的预防及治疗作用。方法：得用小鼠双侧颈总动结扎及反复再灌的手术成小鼠智力下降的脑损伤模型，从行为学方面观察了还少丹对脑损伤小鼠学习记忆 能力的改善作用，并进一步得用受体研究方法考察了该药的脑保护机制。结论：揭示该药具有对抗兴奋性氨基酸毒性的作用。还少丹一学可明显增强脑损伤模型的皮层，海马部位的ＣＡＴ活性。
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| 关 键 词： | 还少丹 脑损伤 学习记忆 中医药疗法 |
Protection Mechanism of Huanshaodan Decoction in Brain |
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| P P Zuo,N Liu,P Y Luo. Protection Mechanism of Huanshaodan Decoction in Brain[J]. Chinese journal of integrated traditional and Western medicine, 1997, 17(7): 420-422 |
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| Authors: | P P Zuo N Liu P Y Luo |
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| Affiliation: | Peking Union Medical College, Department of Pharmacology, Beijing. |
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| Abstract: | OBJECTIVE: To observe the protective effect of Huanshaodan (HSD) in mouse brain in a steady ischemia-reperfusion model. METHODS: Step-through experiment, receptor binding test and choline acetyl-transferase (CAT) activity determination was performed. RESULTS: After HSD treatment, mice made much less mistakes in step-through experiment than sham groups. Meanwhile the 3H-MK801 binding of cerebral cortex and hippocampus tissues was significantly decreased. CAT activity of cerebral cortex and hippocampus tissue were increased respectively. CONCLUSION: HSD might antagonize ischemia injury of brain through modulating excessive activation of glutamate N-methyl-D-Aspartic acid receptors. |
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| Keywords: | Huanshaodan brain injury N-methyl-D-Aspartic acid receptor learning and memory choline acetyltransferase |
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